[Supporting Information S1]:the Physico-chemical properties used in our model.
[Supporting Information S2]:Saccharomyces cerevisiae benchmark dataset has 340 replication origin samples and 342 negative samples.
[Supporting Information S3]:Schizosaccharomyces pombe benchmark dataset has 338 replication origin samples and 335 negative samples.
[Supporting Information S4]:Kluyveromyces lactis benchmark dataset has 147 replication origin samples and 147 negative samples.
[Supporting Information S5]:Pichia pastoris benchmark dataset has 306 replication origin samples and 303 negative samples.